B-cell receptor lineages
Reconstructing evolutionary relationships among B cells helps explain how adaptive immune responses mature. I study algorithmic approaches for inferring cellular ancestry from B-cell receptor (BCR) sequencing data.
M.Sc. student & researcher
Seyyed Mohammad Hamidi
Algorithms for understanding immune complexity.
I study computational immunology and biological data at ComputImm Laboratory, Shahid Beheshti University, supervised by Prof. Changiz Eslahchi. As an M.Sc. student in Algorithms and Computation Theory, I connect algorithmic research with reproducible scientific software.
About this structure
PDB · 1IGT
The Mab231 antibody
This is Mab231, an intact mouse IgG2a antibody developed to recognize antigens associated with canine lymphoma. Its two Fab arms bind antigens, while the Fc stem interacts with other components of the immune system. Determined by X-ray crystallography at 2.8 Å resolution, the structure reveals asymmetric arms joined through a flexible hinge.
View the PDB recordResearch directions
Two problems in computational biology, approached through algorithms and probabilistic modeling.
Modeling responses to drug combinations
Combination responses depend on paired drug doses and cellular context. I work on forward and inverse probabilistic models linking gene-expression profiles, dose pairs, and cellular inhibition.
Featured scientific software
All projectsPython · AIRR
ClonoDefs
Group B-cell receptor sequences using five explicit clonotype definitions, with settings and outputs preserved.
Python · PyTorch
DuoDose
An experimental probabilistic model of two-drug doses for a requested response, conditioned on cell-line gene-expression profiles.
C++17 · CMake
C++ IgBLAST Wrapper
Bundle NCBI IgBLAST with human immunoglobulin reference resources and enrich its AIRR output.
Background
Before focusing on computational biology at Shahid Beheshti University, I earned my B.Sc. in Electrical Engineering (Control) at Amirkabir University of Technology, where my thesis explored transformer models for Persian poetry generation.
- M.Sc. · Algorithms and Computation Theory
- Shahid Beheshti University · 2025–present
- B.Sc. · Electrical Engineering (Control)
- Amirkabir University of Technology
Interested in collaborating or discussing my work?
Feel free to reach out with questions about my research, software implementations, or academic opportunities.